Targeted Therapies
 /  Targeted Therapies

Some patients have a mutation in the protein called BRAFV600 which can cause the cell to grow in an uncontrolled manner, resulting in the formation of a tumour. Targeted therapies can be used to block uncontrolled signals and slow down the rate of tumour growth.

Tafinlar (dabrafenib) and Mekinist (trametinib)

Tafinlar and Mekinist are treatments used in combination for those with the BRAFV600 mutation.
They are both protein inhibitors and target the pathways that allow tumour growth, slowing down cell growth and division.

Tafinlar and Mekinist used in combination form a double blockade and the combination of the two inhibitors (BRAF inhibitor and MEK inhibitor) has shown significantly improved survival and delayed drug resistance over the use of a single agent.

This treatment combination is taken orally (in pill form) each day.

Tafinlar and Mekinist can cause side effects. The most common side effects include fever,diarrhoea, nausea, vomiting, skin rash, swelling of ankles or feet and eye problems.

The combination of Tafinlar and Mekinist is listed on the Pharmaceutical Benefits Scheme (PBS) for the treatment of BRAFV600 mutation-positive unresectable metastatic melanoma.

Zelboraf (vemurafenib) and Cotellic (cobimetinib)

Zelboraf and Cotellic are treatments used in combination for those with the BRAFV600 mutation.
They are both protein inhibitors and target the pathways that allow tumour growth, slowing down cell growth and division.

Zelboraf and Cotellic used in combination form a double blockade and the combination of the two inhibitors (BRAF inhibitor and MEK inhibitor) has shown significantly improved survival and delayed drug resistance over the use of a single agent.

This treatment combination is taken orally (in pill form) each day.

Zelboraf and Cotellic can cause side effects. The most common side effects include sunburn or sun sensitivity, Cutaneous Squamous Cell Carcinoma (lesions) skin rash, blistering, swelling of the face, hands, or soles of the feet, joint discomfort and eye problems.

The combination of Zelboraf and Cotellic is not listed on the PBS

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